Maternal pre-existing diabetes and gestational diabetes and the prevalence of septal defects in the offspring

Abstract Background and introduction Maternal pre-existing gestational diabetes affect approximately 6% of all pregnancies in Denmark are well known risk factors for congenital heart disease (CHD). Worldwide, CHD is the most common defect a leading cause infant death. The association between maternal diabetes, offspring has previously been studied, however, these studies have limited by small study cohorts and/or registry without systematic transthoracic echocardiography (TTE) children. Purpose To assess prevalence atrial ventricular septal defects (ASD VSD) children born to mothers with or TTE, large, population-based cohort neonates. Method Systematic, standardized TTE was performed neonates included 2016 2018. For present study, VSD cases controls assessed entire who underwent within 30 days birth, whom information regarding available (n=24,921). ASD sub-cohort (n=12,682) same inclusion criteria an interatrial communication had classified as patent oval foramen according validated algorithm. defined size ≥4mm, location inferior 1/3 septum, multiple communications. flow across interventricular septum colour Doppler mode one more views. VSDs were either muscular, perimembranous, subarterial. Information about collected from review mother's medical records Obstetrical Database maintained participating hospitals. Cases compared controls, which here consists full ASD, respectively, after excluding cases. Results median age at examination 11 [interquartile range (IQR) 7; 14] 48% female. 3.1% 3.3% among RR 1.00 (95% CI 0.99–1.01, p=0.771). There no difference when comparing subtypes (table 1). In 12,682 (median 12 [IQR, 8; 15], female), presence found 7.3% 5.9% 0.81 0.59–1.13, p=0.214). Conclusion large infants, we did not find increased VSD, nor any controls. Funding Acknowledgement Type funding sources: Public hospital(s). Main source(s): Capital Region Denmarks Research Fund.The Council Herlev Gentofte Hospital.